Eco-Friendly Synthesis, Characterization and Biological Significance of Some Transition Metal Complexes

Abstract

This work details the synthesis and comprehensive structural analysis of VO(IV) and Co(II) derived from 2-pyridine carboxaldehyde with isoniazide (PCI) have been synthesized by conventional as well as microwave methods. Elemental analysis, FTIR, FAB-mass, molar conductance, electronic spectra and magnetic susceptibility have characterized these compounds. The complexes are coloured and stable in air. Analytical data revealed that all the complexes exhibited a 1:1 (metal: ligand) ratio with a coordination number of 4 or 6. FAB-mass data show a degradation pattern of the complexes. The Schiff base and metal complexes show a good activity against the gram-positive bacteria, Staphylococcus aureus and gram-negative bacteria, Escherichia coli and fungi, Aspergillus niger and Candida albicans. The antimicrobial results also indicate that the metal complexes are better antimicrobial agents as compared to the Schiff base. Chelation tends to make the ligand act as a more powerful and potent bactericidal agent. Further chelation can help in MDR problems.