Journal of Advanced Scientific Research

A Review on Coronary Stents: With Polymers and without Polymers

Geetha Karra — 2024-04-02

Polymers have many uses in cardiology, such as coating matrices for drug-eluting stents and stent platforms (scaffolds) during coronary vascular intervention. Current research focuses on biodegradable polymers rather than permanent polymers. Their use may help to lessen undesirable events such as in-stent restenosis, late stent-thrombosis, and hypersensitivity reactions since they disintegrate once their purpose is served. This paper discusses factors affecting tissue and blood cell functions that should be taken into account when assessing the biocompatibility of stent polymers to improve physiologically suitable 3 Polymers are frequently used in cardiology, particularly in coronary vascular intervention, as coating matrices for drug-eluting stents and stent platforms (scaffolds). In addition to permanent polymers, biodegradable polymers are the subject of current study. Since they break down once their function is completed, using them may help prevent unfavorable outcomes such as in-stent restenosis, late stent thrombosis, and hypersensitivity reactions. This review discusses aspects of blood cell and tissue operations that should be taken into account to evaluate the biological compatibility of stent polymer compounds to improve physiologically relevant features after examining recent literature on polymers used in applications related to cardiology. The shape, difference, motion, and future of vascular cells can all be significantly influenced by the characteristics of the supporting material that they are grown. Lastly, a summary of techniques for measuring these parameters in a physiological setting will be provided.

Contribution of Unani Physicians in Tashrīḥ al-Raḥim (Anatomy of the Uterus): A Systematic Review

Samreen Khan — 2024-04-02

The Unani System of Medicine pioneered in Greece and was developed by Arabs into an elaborate medical science based on the frame work of the teaching of Buqrāṭ (Hippocrates) and Jālīnūs (Galen). Since that time Unani Medicine has been known as Grek-o-Arab Medicine. Tashrīḥ-al-badan (Anatomy) is one of the oldest basic sciences. In Alexandria (1^st recorded school of anatomy) where the renowned anatomical teachers Herophilus and Erasistratus dissected the human body and described many of its structures. Herophilus (335-280 B.C.) and Aristotle (384-322 B.C.) were the earliest who emphasized about the knowledge of human anatomy and laid the foundation of the subject, Tashrīḥ-al-badan (Anatomy). Galen's description of the "one-sex model" depicted the female and male reproductive organs as homologous anatomical structures, with differences only in location, size, and complexity. Woman is given prime importance in our classics since ancient times as it is the root cause for progeny. This paper enlightens the admirable work done by Unani physicians, who compiled their observations and research work about Tashrīḥ al-Raḥim (anatomy of uterus) which is present in our ancient Unani literature. To compile the contribution of Unani physicians in anatomy of uterus we search and collect the material from Unani classical reference books Al-Qānūn fi’l Ṭibb, Kāmil al-Ṣanā‘a al-Ṭibbiyya, Al-Manṣūrī fi’l Ṭibb, Modern books, Journal, Research Paper, and Online resources etc.

Green Synthesis and Characterization of Zinc Oxide Nanoparticles by Using Numerous Plants: A Review

Harshal S Kharde — 2024-04-02

Nanotechnology deals with the production and usage of material with nanoscale dimension. The nanoscale dimension provides nanoparticles with a large surface area to volume ratio and thus very specific properties. Zinc oxide nanoparticles (ZnO NPs) had been in recent studies due to its large bandwidth and high exaction binding energy and it has potential applications like antibacterial, antifungal, anti-diabetic, antiinflammatory, wound healing, antioxidant and optic properties. Due to the large rate of toxic chemicals and extreme environment employed in the physical and chemical production of these NPs, green methods employing the use of plants, fungus, bacteria and algae have been adopted. This review is a comprehensive study of the synthesis and characterization methods used for the green synthesis of ZnO NPs using different biological sources.

Evaluation of Neuroprotective effect of Bioactive compounds of Mucuna monosperma in PD lines of Drosophila melanogaster

Sneha S — 2024-04-02

Parkinson's Disease (PD) is a progressive neurodegenerative disorder that affects the nervous system. Oxidative stress (OS) plays an important role in the degeneration of dopaminergic neurons in PD. Ongoing research is focused on discovering new plant sources and developing alternative methods of production to meet the increasing demand for the treatment of Parkinson's disease. Ethnopharmacognosy plays a vital role in bridging traditional knowledge with modern science, and the screening of natural compounds from edible plants is a valuable approach to discovering new therapeutic agents. Hence, the exploration of plants and their bioactive compounds for drug development is an ongoing and promising field. This paper embodies results on neuroprotective property of Mucuna monosperma (MM), two major bioactive compounds namely l-3,4-dihydroxyphenylalanine (L-DOPA) and Ursolic acid were identified and isolated by Prep-HPLC and Column chromatography respectively. Further, quantified the isolated compounds by HPLC. The antioxidant property of crude, L-Dopa and Ursolic acid were scrutinized and verified through DPPH and Nitric oxide scavenging assay. To evaluate the neuroprotective property and anti-ageing effect of bioactive compounds, negative geotaxis, courtship behavior and longevity studies were made in Transgenic PD line of Drosophila melanogaster against oxidative stress status. Result reveals that the climbing ability, courtship behaviors and longevity were significantly increased in PD lines (Elva/SNCA-A30P) under stress conditions. Further it was noticed that synergetic effects of Ursolic acid along with L-Dopa showed excellent result.

Formulation and Evaluation of Polyherbal Antidiabetic Capsules

Geetha Karra — 2024-04-02

This research aims to create and assess polyherbal anti-diabetic capsules using medicinal plants with anti-diabetic properties. The formulation process involves carefully choosing botanical extracts with antidiabetic properties, verifying their bioactive compounds, and blending them to form a polyherbal blend with maximum antidiabetic potential while ensuring safety.Micro Crystalline Cellulose is used in encapsulating a polyherbal mix for stability, release, and patient convenience. Capsule dosage form is recommended for improved treatment adherence. Efficiency is assessed through in vitro studies on enzymes involved in glucose metabolism and their inhibitory effect.The results of this study offer a viable natural option for managing diabetes by providing important insights into the composition of polyherbal antidiabetic capsules. Several botanical extracts with complimentary modes of action have the potential to be combined, offering a comprehensive strategy to address the complex nature of diabetes mellitus. Nevertheless, more clinical studies including diabetes patients are necessary to confirm the long-term advantages, safety, and effectiveness of the capsules. The creation of polyherbal antidiabetic capsules may present novel approaches to the management of diabetes, enhancing glycaemic control and elevating the standard of living for those with the condition.

Isolation and Characterization of Rhizobacteria from Soil and Its Efficiency as Plant Growth- Promoting Microbes

Monal Ingawale — 2024-04-02

Rhizosphere is the soil environment where the plant root is available and is a zone of maximum microbial activity resulting in a confined nutrient pool in which essential macro-and micronutrients are extracted. The microbial population present in the rhizosphere is relatively different from that of its surroundings due to the presence of root exudates that function as a source of nutrients for microbial growth. Among all these interactions, those resulting in symbiotic and non-symbiotic nitrogen fixation are considerably important. In recent years, the use of bacteria (rhizobacteria) to promote plant growth has increased in several regions of the world and has acquired relevant importance in developing countries that are the producers of raw materials for food.In the present study Rhizobacteria was isolated from the soil and the production of IAA and phosphate solubilisatrion was studied. The effect of PGPR was done on Mat seeds (matki) and black-eyed peaseeds (chawali) on the growth of plants.